Impact of intercurrent respiratory infections on lung health in infants born <29 weeks with bronchopulmonary dysplasia

J. B. Taylor, M. F. Nyp, M. Norberg, H. Dai, H. Escobar, E. Ellerbeck, W. E. Truog

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Objective:Assess the impact of intercurrent respiratory infections in infants <29 weeks gestational age (GA).Study design:A retrospective cohort study of 111 infants born <29 weeks GA, controlling for bronchopulmonary dysplasia (BPD) severity and assessing pulmonary health over the first year of life through oxygen, diuretic and inhaled steroid use.Result:Regression analysis showed viral infections increased oxygen use (odds ratio (OR) of 15.5 (confidence interval (CI)=3.4, 71.3)). The trend test showed increasing numbers of viral infections were associated with increased oxygen (OR (95% CI)=6.4 (2.3 to 17.4), P=0.0003), diuretic (OR (95% CI)=2.4 (1.1to 5.2), P=0.02) and inhaled steroid use (OR (95% CI)=2.2 (1.003 to 5.2), P=0.049), whereas bacterial infections were not.Conclusion:Viral infections caused more long-term pulmonary morbidity/mortality than bacterial infections on premature lung health, even when controlling for BPD.

Original languageEnglish (US)
Pages (from-to)223-228
Number of pages6
JournalJournal of Perinatology
Volume34
Issue number3
DOIs
StatePublished - Mar 2014

Keywords

  • bronchopulmonary dysplasia
  • late-effects
  • prematurity
  • pulmonary outcomes
  • viral infection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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