Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection

G. Shor-Posner, D. Feaster, N. T. Blaney, H. Rocca, E. Mantero-Atienza, J. Szapocznik, C. Eisdorfer, K. Goodkin, M. K. Baum

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Objective: Inadequate vitamin B6 status has been associated with altered neuropsychiatric function, possibly through its effect on the metabolism of neurotransmitters, including serotonin (5-HT). The present eighteen month longitudinal study evaluated the relationship between vitamin B6 status and psychological distress in HIV-1 infected individuals, controlling for the influence of negative life events, social support and coping style. Method: Biochemical measurements of nutritional status, and dietary intake evaluations were obtained in HIV-1 seropositive homosexual men, (at baseline: CDC Stages II and III, n = 70; Stage IVA, IVC2 n = 18) at six month intervals. Alterations in nutrient status (e.g., vitamin B6 adequate to inadequate; inadequate to adequate), were compared with changes in psychological distress, measured by the Profile of Mood States, using a multiple regression analysis. Results: A significant decline in psychological distress was demonstrated with normalization of vitamin B6 status from inadequate to adequate status (p < 0.02). A decrease in psychological distress was also observed with increased tryptophan intake in subjects who were vitamin B6 adequate (p < 0.02). Conclusions: Significant effects for the nutritional variables remained even when negative life event stressors, social support, and coping style were controlled, suggesting that vitamin B6 status may be an important co-factor in determining level of psychological distress over time in HIV-1 infected individuals.

Original languageEnglish (US)
Pages (from-to)209-222
Number of pages14
JournalInternational journal of psychiatry in medicine
Issue number3
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


Dive into the research topics of 'Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection'. Together they form a unique fingerprint.

Cite this