Impaired dilatation of cerebral arterioles in chronic hypertension

Donald D. Heistad, William G. Mayhan, Peter Coyle, Gary L. Baumbach

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Several mechanisms impair cerebral vasodilatation during chronic hypertension. First, the external diameter of cerebral arterioles is reduced during chronic hypertension by structural ‘remodeling’. Thus, both vascular hypertrophy and remodeling result in encroachment on the lumen. Second, endothelium-dependent dilatation of cerebral vessels is impaired during chronic hypertension. Third, blood flow through cerebral collaterals is impaired by chronic hypertension, so that an important compensatory mechanism is compromised. Impaired vasodilator responses, together with limitation of increases in collateral blood flow, may predispose to cerebral ischemia and stroke during chronic hypertension.

Original languageEnglish (US)
Pages (from-to)258-262
Number of pages5
JournalJournal of Vascular Research
Issue number2-5
StatePublished - 1990
Externally publishedYes


  • Cerebral circulation
  • Collateral circulation
  • Endothelium-dependent vasodilatation
  • Hypertension
  • Vascular remodeling

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


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