TY - JOUR
T1 - Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination
AU - Mehta, Nishaki
AU - Cunningham, Coleen K.
AU - Flynn, Patricia
AU - Pepe, Joyce
AU - Obaro, Stephen
AU - Kapogiannis, Bill G.
AU - Bethel, James
AU - Luzuriaga, Katherine
N1 - Funding Information:
We acknowledge the contribution of the investigators and staff at the following ATN sites that participated and enrolled subjects into this study: Children's Diagnostic and Treatment Center, Fort Lauderdale, FL (Puga, Leonard, Eysallanne, Inman); Children's Hospital of Los Angeles, Los Angeles, CA (Belzer, Tucker); Children's National Medical Center, Washington, DC (D’Angelo, Trexler, Hagler, Klamberg); John H. Stroger Jr. Hospital of Cook County and the Ruth M. Rothstein CORE Center, Chicago, IL (Martinez, Bojan, Jackson); Montefiore Medical Center, Bronx, NY (Futterman, Enriquez-Bruce, Campos); Mount Sinai Medical Center, New York, NY (Levin, Geiger, Lee); St. Jude Children's Research Hospital, Memphis, TN (Flynn, Gaur, Dillard, McKinley); Tulane University Health Sciences Center, New Orleans, LA (Abdalian, Baker, Kozina); University of Maryland, Baltimore, MD (Peralta, Flores, Gorle, Collinetti); University of Puerto Rico, San Juan, PR (Febo, Ayala-Flores, Fuentes); University of South Florida, Tampa, FL (Emmanuel, Lujan-Zilbermann, Callejas, Julian). Additional support was provided by the Pediatric AIDS Clinical Trials Group (PACTG)/International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT) funded by grant No. 5 U01 AI068632-02. The following PACTG/IMPAACT sites also participated and enrolled subjects into this study: Hospital San Juan, Rio Piedras, Puerto Rico (Acevedo, Gonzalez, Angeli, Marrero, Perez); St. Jude Children's Research Hospital, Memphis, TN (Flynn, Patel, Dillard, Wride); University of Alabama at Birmingham, Birmingham, AL (Pass, Craine, Beatty); University of California at San Diego, San Diego, CA (Spector, Viani, Norris, Stangl).
Funding Information:
Funding: This work was supported by the National Institutes of Health Grants R01-AI032391 , K24-HD001489 , and P30-AI042845 (to K.L.) and by The Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) from the National Institutes of Health (U01 HD 040533 and U01 HD 040474) through the National Institute of Child Health and Human Development (B. Kapogiannis, R. Hazra, S. Lee, C. Worrell), with supplemental funding from the National Institutes on Drug Abuse (N. Borek) and Mental Health (P. Brouwers, S. Allison). The study was scientifically reviewed by the ATN's Therapeutic Leadership Group. Network, scientific and logistical support was provided by the ATN Coordinating Center (C. Wilson, C. Partlow) at The University of Alabama at Birmingham. Network operations and analytic support was provided by the ATN Data and Operations Center at Westat, Incorporated (J. Korelitz, B. Driver). Additional support for this study was provided by the P30 AI064518-04 (Duke Center for AIDS Research; CKC) and by grants from the General Clinical Research Center (GCRC) Program of the National Center for Research Resources, National Institutes of Health, Department of Health and Human Services. The following grants provided support: Children's National Medical Center , GCRC Grant M01RR020359 and University of California at San Francisco , GCRC Grant M01RR00083-42 and Pediatric Clinical Research Grant M01RR01271 . The Tulane/LSU Clinical Trial Research Center was supported in part or in full by the Louisiana Board of Regents Clinical and Translational Research, Education, and Commercialization Project. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the funding agencies
PY - 2010/5/7
Y1 - 2010/5/7
N2 - Hepatitis B-specific memory B cell (HSMBC) frequencies were measured following hepatitis B vaccination in 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >10 mIU/ml at study week 28 was strongly associated with the detection of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was observed. In HIV uninfected individuals, antibody titers >1000 mIU/ml were associated with higher HSMC frequencies. Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals.
AB - Hepatitis B-specific memory B cell (HSMBC) frequencies were measured following hepatitis B vaccination in 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >10 mIU/ml at study week 28 was strongly associated with the detection of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was observed. In HIV uninfected individuals, antibody titers >1000 mIU/ml were associated with higher HSMC frequencies. Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals.
KW - HIV
KW - Hepatitis B vaccines
KW - Memory B cells
UR - http://www.scopus.com/inward/record.url?scp=77953137946&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953137946&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2010.03.022
DO - 10.1016/j.vaccine.2010.03.022
M3 - Article
C2 - 20356567
AN - SCOPUS:77953137946
VL - 28
SP - 3672
EP - 3678
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 21
ER -