Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination

Nishaki Mehta, Coleen K. Cunningham, Patricia Flynn, Joyce Pepe, Stephen Obaro, Bill G. Kapogiannis, James Bethel, Katherine Luzuriaga

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Hepatitis B-specific memory B cell (HSMBC) frequencies were measured following hepatitis B vaccination in 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >10 mIU/ml at study week 28 was strongly associated with the detection of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was observed. In HIV uninfected individuals, antibody titers >1000 mIU/ml were associated with higher HSMC frequencies. Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals.

Original languageEnglish (US)
Pages (from-to)3672-3678
Number of pages7
JournalVaccine
Volume28
Issue number21
DOIs
StatePublished - May 7 2010
Externally publishedYes

Keywords

  • HIV
  • Hepatitis B vaccines
  • Memory B cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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