Impaired oxidative energy metabolism in aids: a 31p mrs study

E. T. Mannix, M. D. Boska, B. Newcomer, F. Montreal, M. O. Färber

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We have recently reported that tow Os delivery during exercise contributes to poor exercise tolerance in AIDS. To test the hypothesis that a peripheral muscte component may also decrease exercise tolerance in AIDS, we measured ATP production from oxidative (OX PHOS) and anaerobic (anaerobic gfycolysis. An Gty and creatine kinase reaction, CK) sources using "P MRS during 90 s isometric contractions (40% of max) of the soieus-gastrocnemius muscle group in stable AIDS patients (n=4, CD4 count=95±31 SEM); comparisons were made with healthy controls (n=5). AIDS CONTROLS OX PHOS ATP (% of total mM/s) 54.8±9.1 85.5±4.5 An Gly ATP (% of total mM/s) 29.68.8 10.3±3.4 CK ATP (% of total mM/s) 15.6± 1.3 4.2± 1.6 An Gly + CK (% of total mM/s) 45.28.9 14.5±4.5 Intramuscular pH 7.01 ±+0.06 7.07±0.01 Results (meantSEM) indicate: reduced OX PHOS ATP in the AIDS group (p=O.OI4): An Gfy ATP fended to be increased (p=0.061); CK ATP was increased (p=0.001|; An Gly+CK was increased (p=0.017), while pH was not different. Conclusion; since isometric exercise of z40% of max creates an intramuscular environment independent from the effects of systemic O2 delivery, the decrease in OX PHOS ATP observed may reflect HIV-induced mitochondrial damage which contributes fo the poor exercise tolerance often seen in AIDS.

Original languageEnglish (US)
Pages (from-to)A375
JournalFASEB Journal
Issue number3
StatePublished - 1996

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics


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