Impairments of probabilistic response reversal and passive avoidance following catecholamine depletion

Gregor Hasler, Krystal Mondillo, Wayne C. Drevets, James R. Blair

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Catecholamines, particularly dopamine, have been implicated in various aspects of the reward function including the ability to learn through reinforcement and to modify flexibly responses to changing reinforcement contingencies. We examined the impact of catecholamine depletion (CD) achieved by oral administration of alpha-methyl-paratyrosine (AMPT) on probabilistic reversal learning and passive avoidance (PA) in 15 female subjects with major depressive disorder in full remission (RMDD) and 12 healthy female controls. The CD did not affect significantly the acquisition phase of the reversal learning task. However, CD selectively impaired reversal of the 80-20 contingency pair. In the PA learning task, CD was associated with reduced responding toward rewarding stimuli, although the RMDD and control subjects did not differ regarding these CD-induced changes in reward processing. Interestingly, the performance decrement produced by AMPT on both of these tasks was associated with the level of decreased metabolism in the perigenual anterior cingulate cortex. In an additional examination using the affective Stroop task we found evidence for impaired executive attention as a trait abnormality in MDD. In conclusion, this study showed specific effects of CD on the processing of reward-related stimuli in humans and confirms earlier investigations that show impairments of executive attention as a neuropsychological trait in affective illness.

Original languageEnglish (US)
Pages (from-to)2691-2698
Number of pages8
Issue number13
StatePublished - Dec 2009
Externally publishedYes


  • Attention
  • Dopamine
  • Norepinephrine
  • Reinforcement learning
  • Remitted major depressive disorder
  • Stroop

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health


Dive into the research topics of 'Impairments of probabilistic response reversal and passive avoidance following catecholamine depletion'. Together they form a unique fingerprint.

Cite this