TY - GEN
T1 - Implantation methodology development for tissue-engineered-electronic-neural-interface (TEENI) devices
AU - Nunamaker, Elizabeth A.
AU - Spearman, Benjamin S.
AU - Graham, James B.
AU - Atkinson, Eric W.
AU - Desai, Vidhi H.
AU - Shafor, Chancellor S.
AU - Natt, Sruthi
AU - Wachs, Rebecca A.
AU - Schmidt, Christine E.
AU - Judy, Jack W.
AU - Otto, Kevin J.
N1 - Publisher Copyright:
© 2017 IEEE.
PY - 2017/8/10
Y1 - 2017/8/10
N2 - Regenerative peripheral-nerve interfaces are a novel method for integrating with the peripheral nervous system. These devices have the potential to isolate and transduce both afferent (sensory) and efferent (motor) neural signals to produce fine control of advanced prosthetics. We have developed a novel regenerative device comprised of microfabricated polyimide electrode threads supported by a hydrogel scaffold containing methacrylated hyaluronic acid, collagen I, and laminin to enable intimate contact with regenerating axons. While this advanced device holds theoretical promise for establishing a stable chronic neural interface, it also requires a novel surgical approach in comparison to current existing methods of peripheral neural interface technologies. Here we describe the development of the surgical methodology required for successful chronic implantation of the TEENI device in the rat sciatic nerve.
AB - Regenerative peripheral-nerve interfaces are a novel method for integrating with the peripheral nervous system. These devices have the potential to isolate and transduce both afferent (sensory) and efferent (motor) neural signals to produce fine control of advanced prosthetics. We have developed a novel regenerative device comprised of microfabricated polyimide electrode threads supported by a hydrogel scaffold containing methacrylated hyaluronic acid, collagen I, and laminin to enable intimate contact with regenerating axons. While this advanced device holds theoretical promise for establishing a stable chronic neural interface, it also requires a novel surgical approach in comparison to current existing methods of peripheral neural interface technologies. Here we describe the development of the surgical methodology required for successful chronic implantation of the TEENI device in the rat sciatic nerve.
UR - http://www.scopus.com/inward/record.url?scp=85028615698&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85028615698&partnerID=8YFLogxK
U2 - 10.1109/NER.2017.8008343
DO - 10.1109/NER.2017.8008343
M3 - Conference contribution
AN - SCOPUS:85028615698
T3 - International IEEE/EMBS Conference on Neural Engineering, NER
SP - 271
EP - 274
BT - 8th International IEEE EMBS Conference on Neural Engineering, NER 2017
PB - IEEE Computer Society
T2 - 8th International IEEE EMBS Conference on Neural Engineering, NER 2017
Y2 - 25 May 2017 through 28 May 2017
ER -