Implications of HIV PrEP trials results

Fulvia Veronese, Peter Anton, Courtney V. Fletcher, Victor DeGruttola, Ian McGowan, Stephen Becker, Sheryl Zwerski, David Burns

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Six randomized clinical trials have been implemented to examine the efficacy of tenofovir disoproxil fumarate (TDF) and/or TDF/emtricitabine (TDF/FTC) as preexposure prophylaxis for HIV-1 infection (PrEP). Although largely complementary, the six trials have many similar features. As the earliest results become available, an urgent question may arise regarding whether changes should be made in the conduct of the other trials. To consider this in advance, a Consultation on the Implications of HIV Pre-Exposure Prophylaxis (PrEP) Trials Results sponsored by the Division of AIDS (DAIDS) of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), and the Bill and Melinda Gates Foundation (BMGF) was held on January 29, 2010, at the Natcher Conference Center, NIH, Bethesda, MD. Participants included basic scientists, clinical researchers (including investigators performing the current PrEP trials), and representatives from the U.S. Food and Drug Administration (FDA) and the agencies sponsoring the trials: the U.S. Centers for Disease Control and Prevention (CDC), the U.S. Agency for International Development (USAID), the BMGF, and the U.S. NIH. We report here a summary of the presentations and highlights of salient discussion topics from this workshop.

Original languageEnglish (US)
Pages (from-to)81-90
Number of pages10
JournalAIDS Research and Human Retroviruses
Volume27
Issue number1
DOIs
StatePublished - Jan 1 2011

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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    Veronese, F., Anton, P., Fletcher, C. V., DeGruttola, V., McGowan, I., Becker, S., Zwerski, S., & Burns, D. (2011). Implications of HIV PrEP trials results. AIDS Research and Human Retroviruses, 27(1), 81-90. https://doi.org/10.1089/aid.2010.0226