Importance of proper diagnosis for management: Multifocal choroiditis mimicking ocular histoplasmosis syndrome

Elham Hatef, Peykan Turkcuoglu, Mohamed Ibrahim, Yasir Sepah, Matthew Shulman, Jangwon Heo, Jeong Hee Lee, Roomasa Channa, Afsheen Khwaja, Zubir Rentiya, Syed Mahmood Shah, Diana V. Do, Quan Dong Nguyen

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Purpose: The study aims to evaluate a series of patients with initial diagnosis of ocular histoplasmosis syndrome (OHS) with progression and response to treatments consistent with multifocal choroiditis (MFC). Methods: Retrospective review of nine patients referred for management of recurrent OHS lesions. Serology panel was conducted to rule out autoimmune and infectious causes. Results: Clinical examination revealed multiple small, punched-out peripheral chorioretinal scars, and peripapillary atrophy. Histoplasma antigen/antibody was negative in all patients. Fluorescein angiography and optical coherence tomography confirmed active inflammation in five patients. Immunomodulatory therapy (IMT) was initiated to control active inflammation. While on IMT, visual acuity stabilized or improved in three patients with no recurrence of CNV or lesion activities over the follow-up period. Conclusions: MFC may initially masquerade as OHS. Clinical characteristics of recurrent MFC and absence of histoplasma titer may lead to consideration of IMT and other proper treatments for MFC.

Original languageEnglish (US)
Pages (from-to)55-63
Number of pages9
JournalJournal of Ophthalmic Inflammation and Infection
Issue number2
StatePublished - Jun 2011
Externally publishedYes


  • Multifocal choroiditis
  • Ocular histoplasmosis syndrome

ASJC Scopus subject areas

  • Ophthalmology
  • Infectious Diseases


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