Improved survival in murine lupus as the result of selenium supplementation

J. R. O'Dell, J. P. McGivern, H. D. Kay, L. W. Klassen

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Selenium is a trace mineral and a required nutrient for animals and humans. Selenium intake appears to be inversely correlated with the risk of developing cancer. Since immunological effects of selenium have been described we studied the capacity of selenium to modify the lupus-like disease of NZB/NZW female mice. Our data indicate that selenium supplementation (sodium selenite 4 parts per million in the drinking water) significantly improves survival in these autoimmune mice: mean survival 55.6 ± 4.6 weeks (mean ± s.e.) for treated mice versus 36.1 ± 1.9 weeks for controls (P < 0.04). Additionally, selenium supplemented mice had significantly higher natural killer cell activity (P < 0.001). However, no obvious effects of selenium supplementation on autoantibody production were observed.

Original languageEnglish (US)
Pages (from-to)322-327
Number of pages6
JournalClinical and Experimental Immunology
Issue number2
StatePublished - 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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