Improving catalyst scope: Use of multiple aniline substrates to optimize a palladium-catalyzed bisdiene cyclization

James M. Takacs; Jianxin Han

doi:10.1021/ol0488791

Improving catalyst scope: Use of multiple aniline substrates to optimize a palladium-catalyzed bisdiene cyclization

James M. Takacs, Jianxin Han

Chemistry

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

(Chemical Equation Presented) Combinatorial screening of five catalyst precursors and nine ligands with three substituted aniline trapping reagents uncovered a catalyst system that promotes efficient palladium-catalyzed cyclization-trapping with a series of substituted anilines of varying steric and electronic character. The results of the parallel optimization study illustrate the interdependency of the key reaction variables.

Original language	English (US)
Pages (from-to)	3099-3102
Number of pages	4
Journal	Organic Letters
Volume	6
Issue number	18
DOIs	https://doi.org/10.1021/ol0488791
State	Published - Sep 2 2004

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol0488791

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title = "Improving catalyst scope: Use of multiple aniline substrates to optimize a palladium-catalyzed bisdiene cyclization",

abstract = "(Chemical Equation Presented) Combinatorial screening of five catalyst precursors and nine ligands with three substituted aniline trapping reagents uncovered a catalyst system that promotes efficient palladium-catalyzed cyclization-trapping with a series of substituted anilines of varying steric and electronic character. The results of the parallel optimization study illustrate the interdependency of the key reaction variables.",

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N2 - (Chemical Equation Presented) Combinatorial screening of five catalyst precursors and nine ligands with three substituted aniline trapping reagents uncovered a catalyst system that promotes efficient palladium-catalyzed cyclization-trapping with a series of substituted anilines of varying steric and electronic character. The results of the parallel optimization study illustrate the interdependency of the key reaction variables.

AB - (Chemical Equation Presented) Combinatorial screening of five catalyst precursors and nine ligands with three substituted aniline trapping reagents uncovered a catalyst system that promotes efficient palladium-catalyzed cyclization-trapping with a series of substituted anilines of varying steric and electronic character. The results of the parallel optimization study illustrate the interdependency of the key reaction variables.

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Improving catalyst scope: Use of multiple aniline substrates to optimize a palladium-catalyzed bisdiene cyclization

Abstract

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