Improving catalyst scope: Use of multiple aniline substrates to optimize a palladium-catalyzed bisdiene cyclization

James M. Takacs, Jianxin Han

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

(Chemical Equation Presented) Combinatorial screening of five catalyst precursors and nine ligands with three substituted aniline trapping reagents uncovered a catalyst system that promotes efficient palladium-catalyzed cyclization-trapping with a series of substituted anilines of varying steric and electronic character. The results of the parallel optimization study illustrate the interdependency of the key reaction variables.

Original languageEnglish (US)
Pages (from-to)3099-3102
Number of pages4
JournalOrganic Letters
Volume6
Issue number18
DOIs
StatePublished - Sep 2 2004

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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