TY - JOUR
T1 - Improving Outcome in Severe Myasthenia Gravis and Guillain-Barré Syndrome
AU - Hawkes, Maximiliano A.
AU - Wijdicks, Eelco F.M.
N1 - Publisher Copyright:
© 2024. Thieme. All rights reserved.
PY - 2024/6/19
Y1 - 2024/6/19
N2 - When progressive and severe, myasthenia gravis and Guillain-Barré syndrome may have the potential for fatal and unfavorable clinical outcomes. Regardless of important differences in their clinical course, the development of weakness of oropharyngeal muscles and respiratory failure with requirement of mechanical ventilation is the main driver of poor prognosis in both conditions. The need for prolonged mechanical ventilation is particularly relevant because it immobilizes the patient and care becomes extraordinarily complex due to daily risks of systemic complications. Additionally, patients with myasthenia gravis often require long-term immunosuppressive treatments with associated toxicity and infectious risks. Unlike myasthenia gravis, the recovery period is prolonged in Guillain-Barré syndrome, but often favorable, even in the more severely affected patients. Outcome, for a large part, is determined by expert neurocritical care.
AB - When progressive and severe, myasthenia gravis and Guillain-Barré syndrome may have the potential for fatal and unfavorable clinical outcomes. Regardless of important differences in their clinical course, the development of weakness of oropharyngeal muscles and respiratory failure with requirement of mechanical ventilation is the main driver of poor prognosis in both conditions. The need for prolonged mechanical ventilation is particularly relevant because it immobilizes the patient and care becomes extraordinarily complex due to daily risks of systemic complications. Additionally, patients with myasthenia gravis often require long-term immunosuppressive treatments with associated toxicity and infectious risks. Unlike myasthenia gravis, the recovery period is prolonged in Guillain-Barré syndrome, but often favorable, even in the more severely affected patients. Outcome, for a large part, is determined by expert neurocritical care.
KW - Guillain-Barre Syndrome
KW - Neurocritical care
KW - Outcomes
KW - Prognosis
KW - myasthenia gravis
UR - http://www.scopus.com/inward/record.url?scp=85189888358&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85189888358&partnerID=8YFLogxK
U2 - 10.1055/s-0044-1785509
DO - 10.1055/s-0044-1785509
M3 - Article
C2 - 38560985
AN - SCOPUS:85189888358
SN - 0271-8235
VL - 44
SP - 263
EP - 270
JO - Seminars in Neurology
JF - Seminars in Neurology
IS - 3
ER -