Improving signal peptide prediction accuracy by simulated neural network

I. Ladunga, F. Czakó, I. Csabai, T. Geszti

Research output: Contribution to journalComment/debatepeer-review

35 Scopus citations


The accuracy of distinguishing amino-terminal signal peptides from cytosolic proteins has been improved to 95% by combining a neural network classifier with von Heijne's statistical prediction, the latter is itself 85-90% reliable. The network processed not the cleavage site, but amino-terminal 20-residue segments by the 'tiling' algorithm. Concordant positive predictions of both methods led to the safe identification of 496 novel signal peptides from the Protein Identification Resources.

Original languageEnglish (US)
Pages (from-to)485-487
Number of pages3
Issue number4
StatePublished - Oct 1991

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics


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