TY - GEN
T1 - In-silico analysis of the 'memory anti-Naïve' effect in anti-viral cross-reactive responses
AU - Castiglione, Filippo
AU - Ghersi, Dario
AU - Celada, Franco
N1 - Publisher Copyright:
© 2017 IEEE.
PY - 2017/12/15
Y1 - 2017/12/15
N2 - Of the examples of clonal competition for antigen among lymphocytes, the recently predicted 'Memory anti-Naïve' phenomenon occurs when the challenging antigen is not identical to the priming, and will be consequently bound with lower avidity by preexisting memory cells. In this study we use computer modeling and a systematic schedule of viral injections to disentangle the complex relationship between different lineages of effector T cells in the presence of viruses. We measure the antiviral efficiency of memory cells as well as their dominance over naïve cells as a function of the antigenic distance between first and second infection. Our simulation show that at a critical range of antigenic distance memory cells, now unable to clear the infection, can however block the surge of naïve clones thus preventing an effective immune response. This finding motivate us to propose the Memory anti-Naïve phenomenon as the causative mechanism for the classic Original Antigenic Sin phenomenon described in the literature which occurs irregularly in returning pandemics, and also for the less glamorous, but certainly numerous and severe, cases of misfired vaccinations, and viral escapes.
AB - Of the examples of clonal competition for antigen among lymphocytes, the recently predicted 'Memory anti-Naïve' phenomenon occurs when the challenging antigen is not identical to the priming, and will be consequently bound with lower avidity by preexisting memory cells. In this study we use computer modeling and a systematic schedule of viral injections to disentangle the complex relationship between different lineages of effector T cells in the presence of viruses. We measure the antiviral efficiency of memory cells as well as their dominance over naïve cells as a function of the antigenic distance between first and second infection. Our simulation show that at a critical range of antigenic distance memory cells, now unable to clear the infection, can however block the surge of naïve clones thus preventing an effective immune response. This finding motivate us to propose the Memory anti-Naïve phenomenon as the causative mechanism for the classic Original Antigenic Sin phenomenon described in the literature which occurs irregularly in returning pandemics, and also for the less glamorous, but certainly numerous and severe, cases of misfired vaccinations, and viral escapes.
UR - http://www.scopus.com/inward/record.url?scp=85045962096&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045962096&partnerID=8YFLogxK
U2 - 10.1109/BIBM.2017.8217873
DO - 10.1109/BIBM.2017.8217873
M3 - Conference contribution
AN - SCOPUS:85045962096
T3 - Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017
SP - 1433
EP - 1437
BT - Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017
A2 - Yoo, Illhoi
A2 - Zheng, Jane Huiru
A2 - Gong, Yang
A2 - Hu, Xiaohua Tony
A2 - Shyu, Chi-Ren
A2 - Bromberg, Yana
A2 - Gao, Jean
A2 - Korkin, Dmitry
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017
Y2 - 13 November 2017 through 16 November 2017
ER -