Abstract
Synthetic vector-based gene delivery systems continue to gain strength as viable alternatives to viral vectors due to safety and other concerns. DNA release dynamics is key to the understanding and control of gene delivery from nano-systems. Here we describe atomic force microscope application to the understanding of DNA release dynamics from bioreducible polycation-based nano-systems. The two nano-systems are polyplex nanoparticles and layer-by-layer fi lms.
| Original language | English (US) |
|---|---|
| Title of host publication | Methods in Molecular Biology |
| Pages | 183-193 |
| Number of pages | 11 |
| Volume | 948 |
| DOIs | |
| State | Published - 2013 |
| Externally published | Yes |
Publication series
| Name | Methods in Molecular Biology |
|---|---|
| Volume | 948 |
| ISSN (Print) | 10643745 |
Keywords
- DNA release
- Gene delivery
- In situ AFM
- Layer-by-layer film
- Polyplex
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Medicine(all)
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Cite this
Zou, Y., Wan, L., Blacklock, J., Oupicky, D., & Mao, G. (2013). In situ AFM analysis investigating disassembly of DNA nanoparticles and nano-films. In Methods in Molecular Biology (Vol. 948, pp. 183-193). (Methods in Molecular Biology; Vol. 948). https://doi.org/10.1007/978-1-62703-140-0-13