In situ bioprinting: intraoperative implementation of regenerative medicine

Mohamadmahdi Samandari, Azadeh Mostafavi, Jacob Quint, Adnan Memić, Ali Tamayol

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


Bioprinting has emerged as a strong tool for devising regenerative therapies to address unmet medical needs. However, the translation of conventional in vitro bioprinting approaches is partially hindered due to challenges associated with the fabrication and implantation of irregularly shaped scaffolds and their limited accessibility for immediate treatment by healthcare providers. An alternative strategy that has recently drawn significant attention is to directly print the bioink into the patient's body, so-called ‘in situ bioprinting’. The bioprinting strategy and the associated bioink need to be specifically designed for in situ bioprinting to meet the particular requirements of direct deposition in vivo. In this review, we discuss the developed in situ bioprinting strategies, their advantages, challenges, and possible future improvements.

Original languageEnglish (US)
Pages (from-to)1229-1247
Number of pages19
JournalTrends in Biotechnology
Issue number10
StatePublished - Oct 2022
Externally publishedYes


  • bioinks
  • bioprinting
  • handheld printers
  • in situ printing
  • robotic bioprinters

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering


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