In vitro cytotoxicity of echitamine chloride and adriamycin on Ehrlich ascites carcinoma cell cultures

V. Saraswathi; S. Subramanian; Nalini Ramamoorthy; V. Mathuram; S. Govindasamy

In vitro cytotoxicity of echitamine chloride and adriamycin on Ehrlich ascites carcinoma cell cultures

V. Saraswathi, S. Subramanian, Nalini Ramamoorthy, V. Mathuram, S. Govindasamy

Research output: Contribution to journal › Article › peer-review

Abstract

Echitamine chloride (EC), an indole alkaloid extracted from the bark of Alstonia scholaris, was tested for its anticancer activity against Ehrlich ascites carcinoma cell cultures. To compare the efficacy of this compound, adriamycin was given in combination with EC. Because labelled macromolecular fractions are generally defined as DNA, RNA and proteins, the rate of incorporation of ³H-thymidine (in DNA), ³H-uridine (in RNA) and ¹⁴C-glycine (in protein) were studied in mice Ehrlich ascites carcinoma cell cultures. The cell viability and uptake of all the three precursors were inhibited in the drug-treated cell cultures.

Original language	English (US)
Pages (from-to)	167-170
Number of pages	4
Journal	Medical Science Research
Volume	25
Issue number	3
State	Published - 1997
Externally published	Yes

Keywords

Adriamycin
C-glycine
Echitamine chloride
Ehrlich ascites carcinoma
H-thymidine
H-uridine

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "In vitro cytotoxicity of echitamine chloride and adriamycin on Ehrlich ascites carcinoma cell cultures",

abstract = "Echitamine chloride (EC), an indole alkaloid extracted from the bark of Alstonia scholaris, was tested for its anticancer activity against Ehrlich ascites carcinoma cell cultures. To compare the efficacy of this compound, adriamycin was given in combination with EC. Because labelled macromolecular fractions are generally defined as DNA, RNA and proteins, the rate of incorporation of 3H-thymidine (in DNA), 3H-uridine (in RNA) and 14C-glycine (in protein) were studied in mice Ehrlich ascites carcinoma cell cultures. The cell viability and uptake of all the three precursors were inhibited in the drug-treated cell cultures.",

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year = "1997",

language = "English (US)",

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journal = "Medical Science Research",

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T1 - In vitro cytotoxicity of echitamine chloride and adriamycin on Ehrlich ascites carcinoma cell cultures

AU - Saraswathi, V.

AU - Subramanian, S.

AU - Ramamoorthy, Nalini

AU - Mathuram, V.

AU - Govindasamy, S.

PY - 1997

Y1 - 1997

N2 - Echitamine chloride (EC), an indole alkaloid extracted from the bark of Alstonia scholaris, was tested for its anticancer activity against Ehrlich ascites carcinoma cell cultures. To compare the efficacy of this compound, adriamycin was given in combination with EC. Because labelled macromolecular fractions are generally defined as DNA, RNA and proteins, the rate of incorporation of 3H-thymidine (in DNA), 3H-uridine (in RNA) and 14C-glycine (in protein) were studied in mice Ehrlich ascites carcinoma cell cultures. The cell viability and uptake of all the three precursors were inhibited in the drug-treated cell cultures.

AB - Echitamine chloride (EC), an indole alkaloid extracted from the bark of Alstonia scholaris, was tested for its anticancer activity against Ehrlich ascites carcinoma cell cultures. To compare the efficacy of this compound, adriamycin was given in combination with EC. Because labelled macromolecular fractions are generally defined as DNA, RNA and proteins, the rate of incorporation of 3H-thymidine (in DNA), 3H-uridine (in RNA) and 14C-glycine (in protein) were studied in mice Ehrlich ascites carcinoma cell cultures. The cell viability and uptake of all the three precursors were inhibited in the drug-treated cell cultures.

KW - Adriamycin

KW - C-glycine

KW - Echitamine chloride

KW - Ehrlich ascites carcinoma

KW - H-thymidine

KW - H-uridine

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