In vitro cytotoxicity of echitamine chloride and adriamycin on Ehrlich ascites carcinoma cell cultures

V. Saraswathi, S. Subramanian, Nalini Ramamoorthy, V. Mathuram, S. Govindasamy

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Echitamine chloride (EC), an indole alkaloid extracted from the bark of Alstonia scholaris, was tested for its anticancer activity against Ehrlich ascites carcinoma cell cultures. To compare the efficacy of this compound, adriamycin was given in combination with EC. Because labelled macromolecular fractions are generally defined as DNA, RNA and proteins, the rate of incorporation of 3H-thymidine (in DNA), 3H-uridine (in RNA) and 14C-glycine (in protein) were studied in mice Ehrlich ascites carcinoma cell cultures. The cell viability and uptake of all the three precursors were inhibited in the drug-treated cell cultures.

Original languageEnglish (US)
Pages (from-to)167-170
Number of pages4
JournalMedical Science Research
Volume25
Issue number3
StatePublished - 1997

Keywords

  • Adriamycin
  • C-glycine
  • Echitamine chloride
  • Ehrlich ascites carcinoma
  • H-thymidine
  • H-uridine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Saraswathi, V., Subramanian, S., Ramamoorthy, N., Mathuram, V., & Govindasamy, S. (1997). In vitro cytotoxicity of echitamine chloride and adriamycin on Ehrlich ascites carcinoma cell cultures. Medical Science Research, 25(3), 167-170.