Abstract
Echitamine chloride (EC), an indole alkaloid extracted from the bark of Alstonia scholaris, was tested for its anticancer activity against Ehrlich ascites carcinoma cell cultures. To compare the efficacy of this compound, adriamycin was given in combination with EC. Because labelled macromolecular fractions are generally defined as DNA, RNA and proteins, the rate of incorporation of 3H-thymidine (in DNA), 3H-uridine (in RNA) and 14C-glycine (in protein) were studied in mice Ehrlich ascites carcinoma cell cultures. The cell viability and uptake of all the three precursors were inhibited in the drug-treated cell cultures.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 167-170 |
| Number of pages | 4 |
| Journal | Medical Science Research |
| Volume | 25 |
| Issue number | 3 |
| State | Published - 1997 |
Keywords
- Adriamycin
- C-glycine
- Echitamine chloride
- Ehrlich ascites carcinoma
- H-thymidine
- H-uridine
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Cite this
Saraswathi, V., Subramanian, S., Ramamoorthy, N., Mathuram, V., & Govindasamy, S. (1997). In vitro cytotoxicity of echitamine chloride and adriamycin on Ehrlich ascites carcinoma cell cultures. Medical Science Research, 25(3), 167-170.