In vitro evaluation of embolization effects of thermosensitive N-isopropylacrylamide-based copolymer solutions

Feng Tian, Bingqi Zhang, Xiaoli Zhao, Weihang Ji, Xiaowei Li, Guoxiang Cheng, Kangde Yao

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Thermosensitive N-isopropylacrylamide (NIPAAm)-co-(N-propylacrylamide (NPAAm)-co-vinyl pyrrolidone (VP) terpolymers (PNINAVP) were synthesized by conventional free-radical polymerization. The thermoresponsive behaviour of their solutions was investigated by turbidimetry and dynamic contact angle (DCA) measurements. The sol-gel transition of the copolymer solutions occurred reversibly within 30 s, in response to the change of temperature. In vitro embolic model experiments indicated that a 5 wt% solution of 16:16:1 PNINAVP had a satisfactory embolization effect.

Original languageEnglish (US)
Pages (from-to)405-408
Number of pages4
JournalPolymer International
Volume55
Issue number4
DOIs
StatePublished - Apr 2006

Keywords

  • Liquid embolic agent
  • N-isopropylacrylamide
  • N-propylacrylamide
  • Thermosensitive
  • Vinyl pyrrolidone

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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