In vitro generation of early-born neurons from late retinal progenitors

Jackson James, Ani V. Das, Sumitra Bhattacharya, David M. Chacko, Xing Zhao, Iqbal Ahmad

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Evidence suggests that, as development ensues, the competence of neural progenitors is progressively altered, such that they become fated to give rise to neurons of a particular stage. Here, we demonstrate that late retinal progenitors can give rise to retinal ganglion cells (RGCs), an example of an early-born cell type in the retina. A subset of late retinal progenitors in vitro responds to cues that favor RGC differentiation by displaying markers characteristic of RGCs. In addition, mechanisms used during normal RGC differentiation are recruited by these cells toward their differentiation along RGC lineage. Our observations suggest that late neural progenitors may not be irreversibly fated but may appear as such under the constraints dictated by epigenetic cues.

Original languageEnglish (US)
Pages (from-to)8193-8203
Number of pages11
JournalJournal of Neuroscience
Volume23
Issue number23
DOIs
StatePublished - Sep 10 2003

Keywords

  • Ath5
  • Brn3b
  • Differentiation
  • Notch
  • Retinal ganglion cells
  • Stem cells/progenitors

ASJC Scopus subject areas

  • Neuroscience(all)

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