In vitro induction of giant cell tumors from cultured hamster islets treated with N-nitrosobis(2-oxopropyl)amine

Hosei Matsuzaki, Bruno M. Schmied, Alexis Ulrich, Surinder K. Batra, Parviz M. Pour

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Giant cell carcinoma of the pancreas is a rare tumor. Its histogenesis is still controversial. In a Syrian hamster pancreatic cancer model, tumors similar to human giant cell carcinomas have been induced at an extremely low rate of incidence and after the use of high doses of pancreatic carcinogens. Thus far no tumors of giant cell type have been induced by the in vitro treatment of hamster pancreatic ductal cells with the potent pancreatic carcinogen N-nitrosobis(2-oxopropyl)amine (BOP). In the present study we report the induction of giant cell carcinoma from hamster islets treated with BOP in vitro. The results suggest that in hamsters some component of islet cells, probably stem cells, are the origin of giant cell carcinoma.

Original languageEnglish (US)
Pages (from-to)439-443
Number of pages5
JournalAmerican Journal of Pathology
Volume156
Issue number2
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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