In vivo activity of aryl ozonides against Schistosoma species

Jennifer Keiser, Katrin Ingram, Mireille Vargas, Jacques Chollet, Xiaofang Wang, Yuxiang Dong, Jonathan L. Vennerstrom

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

We evaluated the in vivo antischistosomal activities of 11 structurally diverse synthetic peroxides. Of all compounds tested, ozonide (1,2,4-trioxolane) OZ418 had the highest activity against adult Schistosoma mansoni, with total and female worm burden reductions of 80 and 90% (P<0.05), respectively. Furthermore, treatment of S. haematobium-infected mice with OZ418 reduced the total worm burden by 86%. In conclusion, OZ418 is a promising antischistosomal lead compound.

Original languageEnglish (US)
Pages (from-to)1090-1092
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume56
Issue number2
DOIs
StatePublished - Feb 2012

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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