TY - JOUR
T1 - In vivo activity of aryl ozonides against Schistosoma species
AU - Keiser, Jennifer
AU - Ingram, Katrin
AU - Vargas, Mireille
AU - Chollet, Jacques
AU - Wang, Xiaofang
AU - Dong, Yuxiang
AU - Vennerstrom, Jonathan L.
PY - 2012/2
Y1 - 2012/2
N2 - We evaluated the in vivo antischistosomal activities of 11 structurally diverse synthetic peroxides. Of all compounds tested, ozonide (1,2,4-trioxolane) OZ418 had the highest activity against adult Schistosoma mansoni, with total and female worm burden reductions of 80 and 90% (P<0.05), respectively. Furthermore, treatment of S. haematobium-infected mice with OZ418 reduced the total worm burden by 86%. In conclusion, OZ418 is a promising antischistosomal lead compound.
AB - We evaluated the in vivo antischistosomal activities of 11 structurally diverse synthetic peroxides. Of all compounds tested, ozonide (1,2,4-trioxolane) OZ418 had the highest activity against adult Schistosoma mansoni, with total and female worm burden reductions of 80 and 90% (P<0.05), respectively. Furthermore, treatment of S. haematobium-infected mice with OZ418 reduced the total worm burden by 86%. In conclusion, OZ418 is a promising antischistosomal lead compound.
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U2 - 10.1128/AAC.05371-11
DO - 10.1128/AAC.05371-11
M3 - Article
C2 - 22106214
AN - SCOPUS:84862940983
SN - 0066-4804
VL - 56
SP - 1090
EP - 1092
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 2
ER -