In Vivo Delivery of Nitric Oxide-Sensing, Single-Walled Carbon Nanotubes

Nicole M. Iverson, Michael S. Strano, Gerald N. Wogan

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Detection of nitric oxide (NO) in vivo by single-walled carbon nanotubes (SWNT) is based on the fluorescent properties of SWNT and the ability of NO to quench the fluorescence signal. Alterations of the signal can be utilized to detect a small molecule in vivo that has not previously been possible by other assay techniques. The protocols described here explain the techniques used to prepare NO-detecting SWNTs and to administer them to mice by both intravenous and subcutaneous routes. These techniques can also be utilized with other SWNT sensors as well as non-SWNT sensors.

Original languageEnglish (US)
Pages (from-to)93-102
Number of pages10
JournalCurrent protocols in chemical biology
Volume7
Issue number2
DOIs
StatePublished - Jun 1 2015

Keywords

  • hydrogel
  • in vivo
  • intravenous
  • nitric oxide
  • sensor
  • single-walled carbon nanotubes
  • subcutaneous

ASJC Scopus subject areas

  • Medicine(all)

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