In vivo Magnetic Resonance Elastography of mesenchymally derived constructs

Shadi F. Othman, Evan T. Curtis, Huihui Xu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

The multidisciplinary field of tissue engineering (TE) aims to create biological substitutes to restore, maintain, or enhance the function of tissue or whole organs, in which the mechanical properties of replacements are critical to their structure and function. Several techniques have been investigated for measuring the mechanical properties of developing tissues and organs; however, current methods are destructive. The goal of this work is to apply high resolution Magnetic Resonance Elastography (MRE) technique with 100 m in-plane resolution to address a critical problem in TE: nondestructive monitoring and characterization of growing mesenchymal stem cells (MSCs)-based tissue engineered constructs. In this study, MRE is used to assess the development of osteogenic and adipogenic constructs implanted in immunodeficient nude mice. In vivo MRE experiments were conducted at 9.4 T (400 MHz for protons) using an 89 mm vertical bore magnet. Multiple shear waves were presented in the adipogenic constructs in comparison to the osteogenic constructs. This study demonstrated that MRE can be used to non-invasively monitor the growth and development of various types of engineered tissues in vivo.

Original languageEnglish (US)
Title of host publicationITME 2011 - Proceedings
Subtitle of host publication2011 IEEE International Symposium on IT in Medicine and Education
Pages621-624
Number of pages4
DOIs
StatePublished - 2011
Event2011 IEEE International Symposium on IT in Medicine and Education, ITME 2011 - Guangzhou, China
Duration: Dec 9 2011Dec 11 2011

Publication series

NameITME 2011 - Proceedings: 2011 IEEE International Symposium on IT in Medicine and Education
Volume1

Conference

Conference2011 IEEE International Symposium on IT in Medicine and Education, ITME 2011
CountryChina
CityGuangzhou
Period12/9/1112/11/11

Keywords

  • Magnetic Resonance Elastography (MRE)
  • Mechanical property
  • Stiffness
  • Tissue Engineering (TE)

ASJC Scopus subject areas

  • Computer Science Applications
  • Biomedical Engineering
  • Education

Fingerprint Dive into the research topics of 'In vivo Magnetic Resonance Elastography of mesenchymally derived constructs'. Together they form a unique fingerprint.

Cite this