In vivo performance of implantable biodegradable preparations delivering Paclitaxel and Etanidazole for the treatment of glioma

Pavan Kumar Naraharisetti, Benjamin Yung Sheng Ong, Jing Wei Xie, Timothy Kam Yiu Lee, Chi Hwa Wang, Nikolaos V. Sahinidis

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Drug-releasing implants delivering chemotherapeutic and radio-sensitizing agents are beginning to play a major role in the post-surgical eradication of residual glioma in the brain. Benefits from early arresting of tumor growth and tumor recovery dynamics stress the impact of drug release profiles of the implants on the efficacy of the treatment. This paper examines responses of BALB/c nude mice, bearing C6 glioma tumors subcutaneously, to treatments by PLGA microspheres, microparticles and discs-delivering Paclitaxel and Etanidazole. The experimental results are used to correlate the efficacy of treatment to in vitro release profiles from the various formulations. Our study demonstrates that radio-sensitizing effects during irradiation could be achieved by double burst profiles from Etanidazole-loaded discs, when compared to controls 17 days after implantation despite the short half-life of Etanidazole (1.4 h) in vivo. These results also showed inhibited tumor growth on tumor volumes of 59%, 65% and 70% over the blank placebo groups after 21 days of tumor growth for spray-dried microspheres, electrohydrodynamic atomization microparticles and spray-dried discs, respectively.

Original languageEnglish (US)
Pages (from-to)886-894
Number of pages9
JournalBiomaterials
Volume28
Issue number5
DOIs
StatePublished - Feb 2007

Keywords

  • Drug delivery
  • Etanidazole
  • Glioma
  • In vivo
  • Paclitaxel
  • Subcutaneous

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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