In vivo testing of noninvasive ICP monitoring methodology in a porcine model

Jeff A. Hawks, Chase Pfeifer, Max Twedt, Greg Bashford, William Thorell, James W Gigantelli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Research has suggested that elevated intracranial pressure (ICP) can cause damage to the optic nerve and reduce visual acuity. There is a need for noninvasive ICP monitoring devices. A simple, portable device capable of measuring relative changes in ICP using a noninvasive methodology would have a significant impact on clinical care. The methodology presented in this paper utilizes transcranial Doppler ultrasonography to monitor ophthalmic artery hemodynamics while small forces are applied to cornea. In vivo testing using a porcine model results in a correlation between pulsatility or resistivity indices and ICP levels. Specifically, the change in these indices while force is applied decreases as ICP increases. The data collection prototype used in these experiments contained an ultrasound transducer instrumented with a load cell to measure force applied to the cornea. These experiments are an initial step towards adapting the data collection prototype into a handheld noninvasive ICP monitoring device.

Original languageEnglish (US)
Title of host publication17th International Conference on Advanced Vehicle Technologies; 12th International Conference on Design Education; 8th Frontiers in Biomedical Devices
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Electronic)9780791857106
DOIs
StatePublished - 2015
EventASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2015 - Boston, United States
Duration: Aug 2 2015Aug 5 2015

Publication series

NameProceedings of the ASME Design Engineering Technical Conference
Volume3

Other

OtherASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2015
CountryUnited States
CityBoston
Period8/2/158/5/15

ASJC Scopus subject areas

  • Modeling and Simulation
  • Mechanical Engineering
  • Computer Science Applications
  • Computer Graphics and Computer-Aided Design

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  • Cite this

    Hawks, J. A., Pfeifer, C., Twedt, M., Bashford, G., Thorell, W., & Gigantelli, J. W. (2015). In vivo testing of noninvasive ICP monitoring methodology in a porcine model. In 17th International Conference on Advanced Vehicle Technologies; 12th International Conference on Design Education; 8th Frontiers in Biomedical Devices (Proceedings of the ASME Design Engineering Technical Conference; Vol. 3). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/DETC2015-47655