TY - JOUR
T1 - Incomplete hippocampal inversion in schizophrenia
T2 - prevalence, severity, and impact on hippocampal structure
AU - Roeske, Maxwell J.
AU - McHugo, Maureen
AU - Vandekar, Simon
AU - Blackford, Jennifer Urbano
AU - Woodward, Neil D.
AU - Heckers, Stephan
N1 - Funding Information:
Acknowledgements Research reported in this publication was supported by the Charlotte and Donald Test Fund, the National Institute of Health (NIMH) grants R01-MH70560 (SH), R01-MH102266 (NDW), and R01-MH123563 (SV), Jack Martin, MD Research Professor in Psychopharmacology (JUB), the Vanderbilt Psychiatric Genotype/ Phenotype Project, and the Vanderbilt Institute for Clinical and Translational Research (through grant 1-UL-1-TR000445 from the National Center for Research Resources/NIH) and National Institute of Health (NIH) grant T32-GM007347 (MJR).
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature Limited part of Springer Nature.
PY - 2021/9
Y1 - 2021/9
N2 - Incomplete hippocampal inversion (IHI) is an anatomical variant of the human brain resulting from an arrest in brain development, especially prevalent in the left hemisphere. We hypothesized that IHI is more common in schizophrenia and contributes to the well-known hippocampal structural differences. We studied 199 schizophrenia patients and 161 healthy control participants with 3 T MRI to establish IHI prevalence and the relationship of IHI with hippocampal volume and asymmetry. IHI was more prevalent (left hemisphere: 15% of healthy control participants, 27% of schizophrenia patients; right hemisphere: 4% of healthy control participants, 10% of schizophrenia patients) and more severe in schizophrenia patients compared to healthy control participants. Severe IHI cases were associated with a higher rate of automated segmentation failure. IHI contributed to smaller hippocampal volume and increased R > L volume asymmetry in schizophrenia. The increased prevalence and severity of IHI supports the neurodevelopmental model of schizophrenia. The impact of this developmental variant deserves further exploration in studies of the hippocampus in schizophrenia.
AB - Incomplete hippocampal inversion (IHI) is an anatomical variant of the human brain resulting from an arrest in brain development, especially prevalent in the left hemisphere. We hypothesized that IHI is more common in schizophrenia and contributes to the well-known hippocampal structural differences. We studied 199 schizophrenia patients and 161 healthy control participants with 3 T MRI to establish IHI prevalence and the relationship of IHI with hippocampal volume and asymmetry. IHI was more prevalent (left hemisphere: 15% of healthy control participants, 27% of schizophrenia patients; right hemisphere: 4% of healthy control participants, 10% of schizophrenia patients) and more severe in schizophrenia patients compared to healthy control participants. Severe IHI cases were associated with a higher rate of automated segmentation failure. IHI contributed to smaller hippocampal volume and increased R > L volume asymmetry in schizophrenia. The increased prevalence and severity of IHI supports the neurodevelopmental model of schizophrenia. The impact of this developmental variant deserves further exploration in studies of the hippocampus in schizophrenia.
UR - http://www.scopus.com/inward/record.url?scp=85100113806&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85100113806&partnerID=8YFLogxK
U2 - 10.1038/s41380-020-01010-z
DO - 10.1038/s41380-020-01010-z
M3 - Article
C2 - 33437006
AN - SCOPUS:85100113806
SN - 1359-4184
VL - 26
SP - 5407
EP - 5416
JO - Molecular Psychiatry
JF - Molecular Psychiatry
IS - 9
ER -