Increase in hypothalamic nicotinic acetylcholine receptors in prepuberal female rats administered estrogen

Barbara J. Morley, Jorge F. Rodriguez-Sierra, Richard W. Clough

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

In previous studies, it has been reported that the administration of estrogen to prepuberal female rats produces precocious surges in the serum concentrations of luteinizing hormone (LH) and prolactin and the number of synaptic contacts in the arcuate nucleus. In the study reported here, we tested the hypothesis that the concentration of hypothalamic nicotinic acetylcholine receptors is the synaptic event initiating the precocious hormonal surges. A single injection of estrogen was administered to prepuberal female rats on day 25 and the serum concentrations of LH and prolactin and the concentration of the binding sites for α-bungarotoxin (BuTX), a putative nicotinic acetylcholine receptor ligand, were measured on day 27. The concentration of hypothalamic BuTX binding sites was increased by the estrogen treatment, but we found no evidence that this increase in receptors precedes or initiaties the serum hormonal surges.

Original languageEnglish (US)
Pages (from-to)262-265
Number of pages4
JournalBrain Research
Volume278
Issue number1-2
DOIs
StatePublished - Nov 14 1983

Keywords

  • cholinergic receptors
  • estrogen
  • hypothalamus
  • α-bungarotoxin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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