Increased anxiety-like behavior of rats during amphetamine withdrawal is reversed by CRF 2 receptor antagonism

Shawn M. Vuong, Harvey A. Oliver, Jamie L. Scholl, Kathryn M. Oliver, Gina L. Forster

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Withdrawal from psychostimulants increases anxiety states, and amphetamine-treated rats show increased CRF 2 receptors in the serotonergic cell body region, the dorsal raphe nucleus (dRN). In the current study, amphetamine (2.5mg/kg, i.p., 14 days) pre-treated rats spent less time in open arms of the elevated plus maze compared saline pre-treated rats at both 24h or 2 weeks of withdrawal, and CRF 2 receptor antagonism (ASV-30; 2μg/0.5μl) within the dRN reversed the effects of amphetamine withdrawal on anxiety-like behavior. Overall, results suggest that CRF 2 receptor antagonism may be a novel pharmacological target for anxiety states during drug withdrawal.

Original languageEnglish (US)
Pages (from-to)278-281
Number of pages4
JournalBehavioural Brain Research
Volume208
Issue number1
DOIs
StatePublished - Mar 17 2010
Externally publishedYes

Keywords

  • ASV-30
  • Addiction
  • CRF receptor
  • Elevated plus maze
  • Psychostimulant
  • Serotonin

ASJC Scopus subject areas

  • Behavioral Neuroscience

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