Increased granulocyte macrophage-colony stimulating factor concentration in bronchoalveolar lavage fluid from patients with pulmonary alveolar proteinosis

Robert P. Baughman, Debra Romberger, Jeffery A. Whitsett, Anna Kurdowska

Research output: Contribution to journalArticlepeer-review

Abstract

Pulmonary alveolar proteinosis (PAP) is a rare disease that had been treated by whole-lung lavage. Recent reports of success in treating alveolar proteinosis with granulocyte macrophage-colony stimulating factor (GM-CSF) led us to the current study. We measured GM-CSF in the bronchoalveolar lavage (BAL) or whole-lung lavage fluid of five patients with PAP. GM-CSF levels were readily detectable in the BAL fluid. The GM-CSF levels in patients with PAP were similar to those in bacterial and Pneumocystis carinii pneumonia, but significantly higher than in healthy control subjects. Interleukin 8 and 10 concentrations were similar in the BAL fluid from patients with PAP or pneumonia. We studied the BAL fluid for autoantibodies to GM-CSF. In two of five patients, high levels of autoantibodies to GM-CSF were detected whereas GM-CSF autoantibodies were not detected in control subjects. We conclude that in these patients, the PAP was not related to defects in GM-CSF production, and that autoantibodies in the lung fluid may be blocking the effect of GM-CSF in the lung, contributing to the pathogenesis of PAP in some patients.

Original languageEnglish (US)
Pages (from-to)96-101
Number of pages6
JournalJournal of Bronchology
Volume9
Issue number2
DOIs
StatePublished - 2002

Keywords

  • Alveolar proteinosis
  • Autoantibodies
  • Bronchoalveolar lavage
  • GM-CSF

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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