Increased hippocampal CA1 cerebral blood volume in schizophrenia

Pratik Talati, Swati Rane, Samet Kose, Jennifer Urbano Blackford, John Gore, Manus J. Donahue, Stephan Heckers

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Hippocampal hyperactivity has been proposed as a biomarker in schizophrenia. However, there is a debate whether the CA1 or the CA2/3 subfield is selectively affected. We studied 15 schizophrenia patients and 15 matched healthy control subjects with 3T steady state, gadolinium-enhanced, absolute cerebral blood volume (CBV) maps, perpendicular to the long axis of the hippocampus. The subfields of the hippocampal formation (subiculum, CA1, CA2/3, and hilus/dentate gyrus) were manually segmented to establish CBV values. Comparing anterior CA1 and CA2/3 CBV between patients and controls revealed a significant subfield-by-diagnosis interaction. This interaction was due to the combined effect of a trend of increased CA1 CBV (p =.06) and non-significantly decreased CA2/3 CBV (p = 0.14) in patients relative to healthy controls. These results support the emerging hypothesis of increased hippocampal activity as a biomarker of schizophrenia and highlight the importance of subfield-level investigations.

Original languageEnglish (US)
Pages (from-to)359-364
Number of pages6
JournalNeuroImage: Clinical
StatePublished - 2014
Externally publishedYes


  • CA1
  • CA2/3
  • CBV
  • Cerebral blood volume
  • Hippocampus
  • Schizophrenia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience

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