Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans

Nina Sanapareddy, Ryan M. Legge, Biljana Jovov, Amber McCoy, Lauren Burcal, Felix Araujo-Perez, Thomas A. Randall, Joseph Galanko, Andrew Benson, Robert S. Sandler, John F. Rawls, Zaid Abdo, Anthony A. Fodor, Temitope O. Keku

Research output: Contribution to journalArticlepeer-review

167 Scopus citations


Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohns disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1-V2 region of the 16S rRNA gene to characterize adherent bacterial communities in mucosal biopsy samples from 33 subjects with adenomas and 38 subjects without adenomas (controls). Biopsy samples from subjects with adenomas had greater numbers of bacteria from 87 taxa than controls; only 5 taxa were more abundant in control samples. The magnitude of the differences in the distal gut microbiota between patients with adenomas and controls was more pronounced than that of any other clinical parameters including obesity, diet or family history of CRC. This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas.

Original languageEnglish (US)
Pages (from-to)1858-1868
Number of pages11
JournalISME Journal
Issue number10
StatePublished - Oct 2012
Externally publishedYes


  • BMI
  • Colon cancer
  • Commensal bacteria
  • Diagnostic

ASJC Scopus subject areas

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics


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