Indirect traumatic optic neuropathy induced by primary blast: A fluid-structure interaction study

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Abstract

Current knowledge of traumatic ocular injury is still limited as most studies have focused on the ocular injuries that happened at the anterior part of the eye, whereas the damage to the optic nerve known as traumatic optic neuropathy (TON) is poorly understood. The goal of this study is to understand the mechanism of the TON following the primary blast through a fluid-structure interaction model. An axisymmetric three-dimensional (3D) eye model with detailed orbital components was developed to capture the dynamics of the eye under the blast wave. Our numerical results demonstrated a transient pressure elevation in both vitreous and cerebrospinal fluid (CSF). A high strain rate over 100 s 1 was observed throughout the optic nerve during the blast with the most vulnerable part located at the intracanalicular region. The optic nerve deforming at such a high strain rate may account for the axonal damage and vision loss in patients subjected to the primary blast. The results from this work would enhance the understanding of indirect TON and provide guidance in the design of protective eyewear against such injury.

Original languageEnglish (US)
Article number101011
JournalJournal of Biomechanical Engineering
Volume141
Issue number10
DOIs
StatePublished - Oct 2019

Keywords

  • Cerebrospinal fluid pressure
  • Fluid-structure interaction
  • Indirect traumatic optic neuropathy
  • Intraocular pressure
  • Primary blast
  • Strain rate

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physiology (medical)

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