Indispensable roles of mammalian Cbl family proteins as negative regulators of protein tyrosine kinase signaling: Insights from in vivo models

Mayumi Naramura, Vimla Band, Hamid Band

Research output: Contribution to journalShort surveypeer-review

9 Scopus citations

Abstract

All higher eukaryotes utilize protein tyrosine kinases (PTKs) as molecular switches to control a variety of cellular signals. Notably, many PTKs have been identified as proto-oncogenes whose aberrant expression, mutations or co-option by pathogens can lead to human malignancies. Thus, it is obvious that PTK functions must be precisely regulated in order to maintain homeostasis of an organism. Investigations over the past fifteen years have revealed that members of the Cbl family proteins can serve as negative regulators of PTK signaling, and biochemical and cell biological studies have unraveled the mechanistic basis of this regulation. Yet, it is only recently that the field has begun to appreciate the real significance of this novel regulatory apparatus in shaping PTK-mediated signaling in organismic contexts and in human diseases. Here, we discuss recent progress in murine models that are beginning to provide insights into the critical roles of Cbl proteins in physiological pathways, with important implications in understanding how aberrations of Cbl proteins contribute to oncogenesis.

Original languageEnglish (US)
Pages (from-to)159-162
Number of pages4
JournalCommunicative and Integrative Biology
Volume4
Issue number2
DOIs
StatePublished - Mar 2011

Keywords

  • Animal models
  • Cbl
  • E3 ubiquitin ligase
  • Hematology
  • Immunology
  • Leukemia
  • Protein tyrosine kinase
  • RING finger
  • Signal transduction
  • Stem cell

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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