Induced pluripotent stem cells: What lies beyond the paradigm shift

Jesse L. Cox, Angie Rizzino

Research output: Contribution to journalShort surveypeer-review

45 Scopus citations


The discovery that somatic cells can be reprogrammed to become induced pluripotent stem (iPS) cells has ushered in a new and exciting era in regenerative medicine. Since the seminal discovery of somatic cell reprogramming by Takahashi and Yamanaka in 2006, there has been remarkable progress in the characterization of iPS cells and the protocols used to generate them. The new information generated during the past year alone has vastly expanded our understanding of these cells. Accordingly, this review provides a basic overview of the different strategies used to generate iPS cells and focuses on recent developments in the field of iPS cells. In the final section, we discuss three broad, unanswered questions related to somatic cell reprogramming, which are just starting to be addressed.

Original languageEnglish (US)
Pages (from-to)148-158
Number of pages11
JournalExperimental Biology and Medicine
Issue number2
StatePublished - Feb 2010


  • Cell cycle
  • Chromatin remodeling
  • DNA methylation
  • Epigenetic
  • IPS cells
  • Induced pluripotent stem cells
  • Nanog
  • Oct4
  • Reprogramming
  • Sox2
  • X chromosome inactivation
  • mi-RNA

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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