Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons

Ellen G. Duysen, Oksana Lockridge

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The restoration of plasma acetylcholinesterase activity in mice following inhibition by organophosphorus pesticides and nerve agents has been attributed to synthesis of new enzyme. It is generally assumed that activity levels return to normal, are stable and do not exceed the normal level. We have observed over the past 10. years that recovery of acetylcholinesterase activity levels in mice treated with organophosphorus agents (OP) exceeds pretreatment levels and remains elevated for up to 2. months. The most dramatic case was in mice treated with tri-cresyl phosphate and tri-ortho-cresyl phosphate, where plasma acetylcholinesterase activity rebounded to a level 250% higher than the pretreatment activity. The present report summarizes our observations on plasma acetylcholinesterase activity in mice treated with chlorpyrifos, chlorpyrifos oxon, diazinon, tri-ortho-cresyl phosphate, tri-cresyl phosphate, tabun thiocholine, parathion, dichlorvos, and diisopropylfluorophosphate. We have developed a hypothesis to explain the excess acetylcholinesterase activity, based on published observations. We hypothesize that acetylcholinesterase activity is induced when cells undergo apoptosis and that consequently there is a rise in the level of plasma acetylcholinesterase.

Original languageEnglish (US)
Pages (from-to)214-220
Number of pages7
JournalToxicology and Applied Pharmacology
Volume255
Issue number2
DOIs
StatePublished - Sep 1 2011

Keywords

  • Acetylcholinesterase
  • Apoptosis
  • Butyrylcholinesterase
  • Induction
  • Organophosphorus pesticides

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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