Infection and atherosclerosis: Mechanisms involving Chlamydia pneumoniae in cardiovascular disease

Gerald I. Byrne; Scot P. Ouellette; Robert J. Belland

doi:10.1016/S0531-5131(03)01862-4

Infection and atherosclerosis: Mechanisms involving Chlamydia pneumoniae in cardiovascular disease

Gerald I. Byrne, Scot P. Ouellette, Robert J. Belland

Research output: Contribution to journal › Article › peer-review

Abstract

The intracellular bacterium Chlamydia pneumoniae is present in atherosclerotic plaques and may contribute to progression and vulnerability of lesions. Results from animal models support a causal role for C. pneumoniae in atherosclerosis and virulence attributes ascribed to this organism are consistent with this view. Results from recent antibiotic treatment trials have not proven effective, but additional work is needed to define reasons for these failures.

Original language	English (US)
Pages (from-to)	426-429
Number of pages	4
Journal	International Congress Series
Volume	1262
Issue number	C
DOIs	https://doi.org/10.1016/S0531-5131(03)01862-4
State	Published - May 1 2004
Externally published	Yes

Keywords

Atherosclerosis
Chlamydia pneumoniae
Chronic infection
GroEL
Pathogenesis

ASJC Scopus subject areas

Medicine(all)

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10.1016/S0531-5131(03)01862-4

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title = "Infection and atherosclerosis: Mechanisms involving Chlamydia pneumoniae in cardiovascular disease",

abstract = "The intracellular bacterium Chlamydia pneumoniae is present in atherosclerotic plaques and may contribute to progression and vulnerability of lesions. Results from animal models support a causal role for C. pneumoniae in atherosclerosis and virulence attributes ascribed to this organism are consistent with this view. Results from recent antibiotic treatment trials have not proven effective, but additional work is needed to define reasons for these failures.",

keywords = "Atherosclerosis, Chlamydia pneumoniae, Chronic infection, GroEL, Pathogenesis",

author = "Byrne, {Gerald I.} and Ouellette, {Scot P.} and Belland, {Robert J.}",

note = "Funding Information: We thank the patients and family members who participated in this study. This work was supported by grants from the Fritz Thyssen Foundation and the Deutsche Forschungsgemeinschaft (both to C.K.). ",

year = "2004",

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doi = "10.1016/S0531-5131(03)01862-4",

language = "English (US)",

volume = "1262",

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journal = "International Congress Series",

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T1 - Infection and atherosclerosis

T2 - Mechanisms involving Chlamydia pneumoniae in cardiovascular disease

AU - Byrne, Gerald I.

AU - Ouellette, Scot P.

AU - Belland, Robert J.

N1 - Funding Information: We thank the patients and family members who participated in this study. This work was supported by grants from the Fritz Thyssen Foundation and the Deutsche Forschungsgemeinschaft (both to C.K.).

PY - 2004/5/1

Y1 - 2004/5/1

N2 - The intracellular bacterium Chlamydia pneumoniae is present in atherosclerotic plaques and may contribute to progression and vulnerability of lesions. Results from animal models support a causal role for C. pneumoniae in atherosclerosis and virulence attributes ascribed to this organism are consistent with this view. Results from recent antibiotic treatment trials have not proven effective, but additional work is needed to define reasons for these failures.

AB - The intracellular bacterium Chlamydia pneumoniae is present in atherosclerotic plaques and may contribute to progression and vulnerability of lesions. Results from animal models support a causal role for C. pneumoniae in atherosclerosis and virulence attributes ascribed to this organism are consistent with this view. Results from recent antibiotic treatment trials have not proven effective, but additional work is needed to define reasons for these failures.

KW - Atherosclerosis

KW - Chlamydia pneumoniae

KW - Chronic infection

KW - GroEL

KW - Pathogenesis

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DO - 10.1016/S0531-5131(03)01862-4

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VL - 1262

SP - 426

EP - 429

JO - International Congress Series

JF - International Congress Series

SN - 0531-5131

IS - C

ER -

Infection and atherosclerosis: Mechanisms involving Chlamydia pneumoniae in cardiovascular disease

Abstract

Keywords

ASJC Scopus subject areas

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