Infection and immune response in the elderly

Philip W. Smith, Jane S. Roccaforte, Pamela B. Daly

Research output: Contribution to journalArticle

16 Scopus citations


A number of immunologic functions have been shown to decline in an age-related fashion, particularly cell-mediated immunity and antibody response to an immunogen. Underlying degenerative diseases and medications further contribute to the immunologic abnormalities noted in the elderly. The elderly in hospitals and nursing homes are a particularly vulnerable subset, with a high incidence of institutionally acquired infection. Aspects of disease prevention in the elderly are discussed.

Original languageEnglish (US)
Pages (from-to)813-822
Number of pages10
JournalAnnals of Epidemiology
Issue number6
StatePublished - Nov 1992


  • Elderly
  • immunity
  • immunosenescence
  • infection

ASJC Scopus subject areas

  • Epidemiology

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    Smith, P. W., Roccaforte, J. S., & Daly, P. B. (1992). Infection and immune response in the elderly. Annals of Epidemiology, 2(6), 813-822.