Infection of Human Gastrointestinal Cells by HIV-1

Mary Pat Moyer, Rachel I. Huot, Adolph Ramirez, Steven Joe, Monte S. Meltzer, Howard E. Gendelman

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Human immunodeficiency virus (HIV-1) infected and replicated in primary cultures of normal human ileal and colonic epithelial cells. Monocyte-tropic strains (ADA, 24, and 36) were better able to replicate in the gastrointestinal (GI) cells than the T-cell-tropic HIV strain HTLV-IIIB. In some cultures, virus replication persisted through several months. Intestinal epithelium may be an initial target and reservoir for HIV and a vector for virus dissemination and transmission.

Original languageEnglish (US)
Pages (from-to)1409-1415
Number of pages7
JournalAIDS Research and Human Retroviruses
Volume6
Issue number12
DOIs
StatePublished - Dec 1990

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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