Abstract
Human immunodeficiency virus (HIV-1) infected and replicated in primary cultures of normal human ileal and colonic epithelial cells. Monocyte-tropic strains (ADA, 24, and 36) were better able to replicate in the gastrointestinal (GI) cells than the T-cell-tropic HIV strain HTLV-IIIB. In some cultures, virus replication persisted through several months. Intestinal epithelium may be an initial target and reservoir for HIV and a vector for virus dissemination and transmission.
Original language | English (US) |
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Pages (from-to) | 1409-1415 |
Number of pages | 7 |
Journal | AIDS Research and Human Retroviruses |
Volume | 6 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1990 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology
- Virology
- Infectious Diseases