TY - JOUR
T1 - Infectious complications of pentostatin therapy.
AU - Vose, J. M.
AU - Cabanillas, F.
AU - O'Brien, S.
AU - Dang, N.
AU - Drapkin, R.
AU - Foss, F.
PY - 2000/6
Y1 - 2000/6
N2 - Managing the infectious complications associated with pentostatin (Nipent), used alone or in combination with other agents in patients with low-grade lymphomas, poses a significant problem for clinicians. Since there is limited experience with these therapies, definitive treatment recommendations concerning prophylaxis cannot be made. The panel members discussed the use of valacyclovir (Valtrex) to provide prophylaxis for herpes zoster, trimethoprim/sulfamethoxazole for Pneumocystis, and acyclovir (Zovirax) for varicella zoster. They also considered combinations of pentostatin with agents such as interferon, rituximab (Rituxan), and chlorambucil (Leukeran) and their effect on the immune system. The biology of B and T cells was discussed, with an emphasis on clinical application.
AB - Managing the infectious complications associated with pentostatin (Nipent), used alone or in combination with other agents in patients with low-grade lymphomas, poses a significant problem for clinicians. Since there is limited experience with these therapies, definitive treatment recommendations concerning prophylaxis cannot be made. The panel members discussed the use of valacyclovir (Valtrex) to provide prophylaxis for herpes zoster, trimethoprim/sulfamethoxazole for Pneumocystis, and acyclovir (Zovirax) for varicella zoster. They also considered combinations of pentostatin with agents such as interferon, rituximab (Rituxan), and chlorambucil (Leukeran) and their effect on the immune system. The biology of B and T cells was discussed, with an emphasis on clinical application.
UR - http://www.scopus.com/inward/record.url?scp=0034199060&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034199060&partnerID=8YFLogxK
M3 - Article
C2 - 10887644
AN - SCOPUS:0034199060
SN - 0890-9091
VL - 14
SP - 41
EP - 42
JO - Oncology (Williston Park, N.Y.)
JF - Oncology (Williston Park, N.Y.)
IS - 6 Suppl 2
ER -