Inflammasomes and metabolic disorders: Old genes in modern diseases

Gregory R. Robbins, Haitao Wen, Jenny P.Y. Ting

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations

Abstract

Modern medical and hygienic practices have greatly improved human health and longevity; however, increased human life span occurs concomitantly with the emergence of metabolic and age-related diseases. Studies over the past decade have strongly linked host inflammatory responses to the etiology of several metabolic diseases including atherosclerosis, type 2 diabetes (T2D), obesity, and gout. A common immunological factor to these diseases is the activation of the inflammasome and release of proinflammatory cytokines that promote disease progression. Here we review the molecular mechanism(s) of inflammasome activation in response to metabolic damage-associated molecular patterns (DAMPs) and discuss potential targets for therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)297-308
Number of pages12
JournalMolecular Cell
Volume54
Issue number2
DOIs
StatePublished - Apr 24 2014

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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