Inflammation and adaptive immunity in Parkinson's disease

R. Lee Mosley; Jessica A. Hutter-Saunders; David K. Stone; Howard E. Gendelman

doi:10.1101/cshperspect.a009381

Inflammation and adaptive immunity in Parkinson's disease

R. Lee Mosley, Jessica A. Hutter-Saunders, David K. Stone, Howard E. Gendelman

Research output: Contribution to journal › Article › peer-review

139 Scopus citations

Abstract

The immune system is designed to protect the host frominfection and injury.However, when an adaptive immune response continues unchecked in the brain, the proinflammatory innate microglial response leads to the accumulation of neurotoxins and eventual neurodegeneration. What drives such responses are misfolded and nitrated proteins. Indeed, the antigen in Parkinson's disease (PD) is an aberrant self-protein, although the adaptive immune responses are remarkably similar in a range of diseases. Ingress of lymphocytes and chronic activation of glial cells directlyaffect neurodegeneration.With this understanding, newtherapies aimed at modulating the immune system's response during PD could lead to decreased neuronal loss and improved clinical outcomes for disease.

Original language	English (US)
Journal	Cold Spring Harbor Perspectives in Medicine
Volume	2
Issue number	1
DOIs	https://doi.org/10.1101/cshperspect.a009381
State	Published - Jan 2012

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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