TY - JOUR
T1 - Inflammation and adaptive immunity in Parkinson's disease
AU - Mosley, R. Lee
AU - Hutter-Saunders, Jessica A.
AU - Stone, David K.
AU - Gendelman, Howard E.
PY - 2012/1
Y1 - 2012/1
N2 - The immune system is designed to protect the host frominfection and injury.However, when an adaptive immune response continues unchecked in the brain, the proinflammatory innate microglial response leads to the accumulation of neurotoxins and eventual neurodegeneration. What drives such responses are misfolded and nitrated proteins. Indeed, the antigen in Parkinson's disease (PD) is an aberrant self-protein, although the adaptive immune responses are remarkably similar in a range of diseases. Ingress of lymphocytes and chronic activation of glial cells directlyaffect neurodegeneration.With this understanding, newtherapies aimed at modulating the immune system's response during PD could lead to decreased neuronal loss and improved clinical outcomes for disease.
AB - The immune system is designed to protect the host frominfection and injury.However, when an adaptive immune response continues unchecked in the brain, the proinflammatory innate microglial response leads to the accumulation of neurotoxins and eventual neurodegeneration. What drives such responses are misfolded and nitrated proteins. Indeed, the antigen in Parkinson's disease (PD) is an aberrant self-protein, although the adaptive immune responses are remarkably similar in a range of diseases. Ingress of lymphocytes and chronic activation of glial cells directlyaffect neurodegeneration.With this understanding, newtherapies aimed at modulating the immune system's response during PD could lead to decreased neuronal loss and improved clinical outcomes for disease.
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U2 - 10.1101/cshperspect.a009381
DO - 10.1101/cshperspect.a009381
M3 - Article
C2 - 22315722
AN - SCOPUS:84862559822
VL - 2
JO - Cold Spring Harbor perspectives in medicine
JF - Cold Spring Harbor perspectives in medicine
SN - 2157-1422
IS - 1
ER -