Inflammation and adaptive immunity in Parkinson's disease

R. Lee Mosley, Jessica A. Hutter-Saunders, David K. Stone, Howard E. Gendelman

Research output: Contribution to journalArticle

128 Scopus citations

Abstract

The immune system is designed to protect the host frominfection and injury.However, when an adaptive immune response continues unchecked in the brain, the proinflammatory innate microglial response leads to the accumulation of neurotoxins and eventual neurodegeneration. What drives such responses are misfolded and nitrated proteins. Indeed, the antigen in Parkinson's disease (PD) is an aberrant self-protein, although the adaptive immune responses are remarkably similar in a range of diseases. Ingress of lymphocytes and chronic activation of glial cells directlyaffect neurodegeneration.With this understanding, newtherapies aimed at modulating the immune system's response during PD could lead to decreased neuronal loss and improved clinical outcomes for disease.

Original languageEnglish (US)
JournalCold Spring Harbor Perspectives in Medicine
Volume2
Issue number1
DOIs
StatePublished - Jan 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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