Inflammation and Cancer: Role of Tight Junctions

Kristina Pravoverov, Susmita Barman, Saiprasad Gowrikumar, Iram Fatima, Santosh Kumar Yadav, Megan Lynn Otte, Raju Lama Tamang, Mark Primeaux, Amar Bahadur Singh, Punita Dhawan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Tight junctions are critical for the homeostatic maintenance of epithelial barrier integrity, especially in the gastrointestinal tract. In addition, tight junction proteins serve as intermediary molecules in a variety of signaling pathways in both health and disease. Dysregulation of tight junction proteins as both a result of and secondary to infection, autoimmunity, or malignancy can either ameliorate or worsen disease, depending on the context. The intricacies of tissue-and pathology-specific contexts for barrier integrity and tight junction protein signal-ing are still poorly understood, but in this chapter, we will explore how tight junction proteins contribute to gut barrier integrity and how they are affected by inflammation during infection and gut dysbiosis and during inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis. Further, we will discuss the involvement of various tight junction proteins in major oncogenic signaling pathways and how their dysregulation in cancer promotes tumor proliferation, invasion, and metastasis.

Original languageEnglish (US)
Title of host publicationTight Junctions in Inflammation and Cancer
PublisherSpringer Nature
Pages1-47
Number of pages47
ISBN (Electronic)9789819924158
ISBN (Print)9789819924141
DOIs
StatePublished - Jan 1 2023

Keywords

  • Cancer
  • Claudins
  • Inflammation
  • Metastasis
  • Oncogene
  • Proliferation
  • Tight junction

ASJC Scopus subject areas

  • General Medicine
  • General Immunology and Microbiology
  • General Biochemistry, Genetics and Molecular Biology

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