Inflammatory breast cancer in North Africa: Comparison of clinical and molecular epidemiologic characteristics of patients from Egypt, Tunisia, and Morocco

Amr S. Soliman, Celina G. Kleer, Karima Mrad, Mehdi Karkouri, Sherif Omar, Hussein M. Khaled, Abdel Latif Benider, Farhat Ben Ayed, Saad S. Eissa, Mohab S. Eissa, Erin J. McSpadden, An Chi Lo, Kathy Toy, Elizabeth D. Kantor, Quin Xiao, Claire Hampton, Sofia D. Merajver

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Understanding molecular characteristics that distinguish inflammatory breast cancer (IBC) from non-IBC is crucial for elucidating breast cancer etiology and management. We included 3 sets of patients from Egypt (48 IBC and 64 non-IBC), Tunisia (24 IBC and 40 non-IBC), and Morocco (42 IBC and 41 non-IBC). Egyptian IBC patients had the highest combined erythema, edema, peau d'orange, and metastasis among the 3 IBC groups. Egyptian IBC tumors had the highest RhoC expression than Tunisians and Moroccan IBCs (87% vs. 50%, vs. 38.1, for the 3 countries, respectively). Tumor emboli were more frequent in Egyptian IBC than non-IBC (Mean ± SD: 14.1 ± 14.0 vs. 7.0 ± 12.9, respectively) (P < 0.001) and Tunisians (Mean ± SD: 3.4 ± 2.5 vs. 1.9 ± 2.0, respectively) (P < 0.01). There was no difference of emboli in Moroccan tumors (1.7 ± 1.2 vs. 1.8 ± 1.2 for IBC and non-IBC, respectively (P=0.66). This study illustrates that RhoC overexpression and tumor emboli are more frequent in IBC relative to non-IBC from Egypt and Tunisia. Tumors of Moroccans were significantly different from Egyptian and Tunisian tumors for RhoC expression and emboli. Future studies should focus on relating epidemiologic factors and clinical pictures to molecular features of IBC in these and other populations.

Original languageEnglish (US)
Pages (from-to)159-169
Number of pages11
JournalBreast Disease
Volume33
Issue number4
DOIs
StatePublished - 2011

Keywords

  • Egypt
  • Inflammatory breast cancer
  • Morocco
  • North Africa
  • RhoC
  • Tunisia
  • tumor emboli

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Soliman, A. S., Kleer, C. G., Mrad, K., Karkouri, M., Omar, S., Khaled, H. M., Benider, A. L., Ayed, F. B., Eissa, S. S., Eissa, M. S., McSpadden, E. J., Lo, A. C., Toy, K., Kantor, E. D., Xiao, Q., Hampton, C., & Merajver, S. D. (2011). Inflammatory breast cancer in North Africa: Comparison of clinical and molecular epidemiologic characteristics of patients from Egypt, Tunisia, and Morocco. Breast Disease, 33(4), 159-169. https://doi.org/10.3233/BD-2012-000337