Abstract
Aim: The aim of this pilot study was to track markers of periodontal inflammation and bone resorption associated with decalcified freeze-dried bone allografts. Material and Methods: Eleven subjects completed standardized treatment of intrabony defects ≥3 mm with allografts. Gingival crevicular fluid was collected from the defect site and an adjacent interproximal site within the surgical field at baseline, 2, 4, and 8 weeks post-operatively, and analysed for biochemical markers of inflammation/bone resorption. Probing depth, recession, bleeding on probing, plaque, and 6-month radiographic bone height change were measured. Results: Both prostaglandin E2 (p=0.007) and bone-specific type 1 collagen (p=0.01) increased in crevicular fluid after 2 weeks in the bone graft sites. Matrix metalloproteinase-9 levels remained constant over time. There were positive correlations between prostaglandin levels during the first 8 weeks and bone height change over 6 months. Conclusions: Periodontal bone grafts stimulate an inflammatory response during the first 2 weeks post-operatively, and the potential negative effects of inhibiting prostaglandins post-operatively should be investigated further.
Original language | English (US) |
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Pages (from-to) | 797-804 |
Number of pages | 8 |
Journal | Journal of Clinical Periodontology |
Volume | 34 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2007 |
Keywords
- Bone resorption
- Inflammation
- Matrix metalloproteinase
- Periodontal allografts
- Prostaglandin E
ASJC Scopus subject areas
- Periodontics