TY - CHAP
T1 - Inflammatory potential of diet and health outcomes in pregnancy, infancy, and childhood
AU - Phillips, Catherine M.
AU - Chen, Ling Wei
AU - Andrews, Chloe
AU - Monthé-Drèze, Carmen
AU - Sen, Sarbattama
AU - Brigham, Emily
AU - Han, Yueh Ying
AU - Hanson, Corrine
AU - Litonjua, Augusto
AU - Polańska, Kinga
N1 - Publisher Copyright:
© 2022 Elsevier Inc. All rights reserved.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Diet-associated inflammation affects health outcomes in pregnancy and throughout childhood. Pregnancy is a sophisticated physiological process during which significant transformations occur in the maternal immune system to ensure a successful pregnancy and birth. Excessive systemic and chronic inflammation and immune activation in pregnancy have been linked to adverse maternal pregnancy outcomes that are associated with higher morbidity and mortality during childhood, higher risk of noncommunicable diseases in the child's adult life, and related socioeconomic and healthcare costs. Therefore, identifying potential modifiable determinants of adverse pregnancy, birth, and childhood outcomes is of paramount importance to improving maternal and child health. Maternal diet is an important modifiable behavior, which not only plays an important role in maternal health but also influences neonatal and child health outcomes. We describe the relationship between maternal dietary inflammatory index (DII) and pregnancy outcomes, including gestational weight gain, hypertensive disorders of pregnancy, mode of delivery, gestational diabetes mellitus, breastfeeding outcomes, breast milk composition, and spontaneous abortion. Next, we address the intergenerational influence of maternal DII in pregnancy on offspring health outcomes. We examine the evidence regarding maternal DII associations with offspring birth outcomes, focusing on gestational length, preterm birth, birthweight, and related measures. Further, we examine the long-term associations between maternal DII and a range of offspring health outcomes during childhood. Finally, we turn our attention to childhood dietary inflammation, as determined by the C-DII, and its associations with childhood growth, adiposity, respiratory health, and neurodevelopment. We conclude with some thoughts regarding the current state of the art and look to the future regarding new research avenues.
AB - Diet-associated inflammation affects health outcomes in pregnancy and throughout childhood. Pregnancy is a sophisticated physiological process during which significant transformations occur in the maternal immune system to ensure a successful pregnancy and birth. Excessive systemic and chronic inflammation and immune activation in pregnancy have been linked to adverse maternal pregnancy outcomes that are associated with higher morbidity and mortality during childhood, higher risk of noncommunicable diseases in the child's adult life, and related socioeconomic and healthcare costs. Therefore, identifying potential modifiable determinants of adverse pregnancy, birth, and childhood outcomes is of paramount importance to improving maternal and child health. Maternal diet is an important modifiable behavior, which not only plays an important role in maternal health but also influences neonatal and child health outcomes. We describe the relationship between maternal dietary inflammatory index (DII) and pregnancy outcomes, including gestational weight gain, hypertensive disorders of pregnancy, mode of delivery, gestational diabetes mellitus, breastfeeding outcomes, breast milk composition, and spontaneous abortion. Next, we address the intergenerational influence of maternal DII in pregnancy on offspring health outcomes. We examine the evidence regarding maternal DII associations with offspring birth outcomes, focusing on gestational length, preterm birth, birthweight, and related measures. Further, we examine the long-term associations between maternal DII and a range of offspring health outcomes during childhood. Finally, we turn our attention to childhood dietary inflammation, as determined by the C-DII, and its associations with childhood growth, adiposity, respiratory health, and neurodevelopment. We conclude with some thoughts regarding the current state of the art and look to the future regarding new research avenues.
KW - Birth
KW - Childhood
KW - Developmental origins of health and disease
KW - Dietary inflammatory index
KW - Early life
KW - Maternal
KW - Neurodevelopment
KW - Nutritional programming
KW - Obesity
KW - Pregnancy
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U2 - 10.1016/B978-0-12-822130-3.00004-1
DO - 10.1016/B978-0-12-822130-3.00004-1
M3 - Chapter
AN - SCOPUS:85137910432
SN - 9780128221655
SP - 609
EP - 663
BT - Diet, Inflammation, and Health
PB - Elsevier
ER -