Inflammatory thoughts about glioma gene therapy

Tammy Kielian, William F. Hickey

Research output: Contribution to journalShort surveypeer-review

25 Scopus citations


Gene therapy for treatment of glioma often involves delivery of herpes simplex virus-1 thymidine kinase gene. A new study shows that this approach can induce chronic inflammation, and raises important questions about current adenoviral-based clinical trials (pages 1256-1263).

Original languageEnglish (US)
Pages (from-to)1237-1238
Number of pages2
JournalNature Medicine
Issue number11
StatePublished - Nov 1999
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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