Influence of crosslink density and stiffness on mechanical properties of type I collagen gel

Shengmao Lin, Linxia Gu

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

The mechanical properties of type I collagen gel vary due to different polymerization parameters. In this work, the role of crosslinks in terms of density and stiffness on the macroscopic behavior of collagen gel were investigated through computational modeling. The collagen fiber network was developed in a representative volume element, which used the inter-fiber spacing to regulate the crosslink density. The obtained tensile behavior of collagen gel was validated against published experimental data. Results suggest that the cross-linked fiber alignment dominated the strain stiffening effect of the collagen gel. In addition, the gel stiffness was enhanced approximately 40 times as the crosslink density doubled. The non-affine deformation was reduced with the increased crosslink density. A positive bilinear correlation between the crosslink density and gel stiffness was obtained. On the other hand, the crosslink stiffness had much less impact on the gel stiffness. This work could enhance our understanding of collagen gel mechanics and shed lights on designing future clinical relevant biomaterials with better control of polymerization parameters.

Original languageEnglish (US)
Pages (from-to)551-560
Number of pages10
JournalMaterials
Volume8
Issue number2
DOIs
StatePublished - 2015

Keywords

  • Collagen gel
  • Crosslink density
  • Polymerization
  • Stiffness
  • Tissue engineering

ASJC Scopus subject areas

  • Materials Science(all)

Fingerprint Dive into the research topics of 'Influence of crosslink density and stiffness on mechanical properties of type I collagen gel'. Together they form a unique fingerprint.

  • Cite this