Influence of D-glucose on phosphate absorption in the rat proximal tubule

T. F. Knight, H. O. Senekjian, S. Sansom, E. J. Weinman

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The proximal convoluted tubule of the thyroparathyroidectomized rat was perfused in vivo to examine the effects of D-glucose on phosphate absorption. The addition of 5.6 mM D-glucose to the perfusion solution resulted in a significantly lower tubular maximum for phosphate of 6.2±0.5 pmol/min/mm as compared to 12.0±0.7 pmol/min/mm when no glucose was present (p<0.001). 10-4 M phloridzin had no significant effect on phosphate transport, and when both D-glucose and phloridzin were added to the perfusion solution, phosphate absorption averaged 10.6±0.6 pmol/min/mm, a value not significantly different from that obtained with the perfusion solution containing no D-glucose. These findings indicate that D-glucose in the lumen of the proximal tubule inhibits phosphate absorption. This effect of D-glucose on phosphate transport requires the transport of the D-glucose but does not appear to be due to an interaction of the two substances at the luminal surface of the proximal tubular cells.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalMineral and Electrolyte Metabolism
Volume4
Issue number1
StatePublished - 1980

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry

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