Rats were fed an alcohol-containing diet for periods of 30 days and 60 days. The feeding of this diet produced an accumulation of N5-methyltetrahydrofolate and a decrease in the pool size of betaine in livers at both time periods. Hepatic choline was elevated as a result of the ethanol but phosphorylcholine and the activities of choline kinase and choline oxidase did not change. These findings suggest that betaine may substitute for N5-methyltetrahydrofolate as a methylator of homocysteine in methionine synthesis when methylation by N5-methyltetrahydrofolate is impaired by ethanol.
|Original language||English (US)|
|Number of pages||2|
|Journal||IRCS Medical Science|
|State||Published - 1981|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)