Influence of gender on dilatation of the basilar artery during diabetes mellitus

William G. Mayhan, Hong Sun, Scott D. Irvine

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The first goal of the present study was to examine the influence of gender on reactivity of the basilar artery. The second goal of this study was to examine the effect of diabetes mellitus on reactivity of the basilar artery in male and female rats. We examined in vivo responses of the basilar artery in male and female nondiabetic and diabetic rats in response to a nitric oxide synthase (NOS)-dependent (acetylcholine) and -independent (nitroglycerin) agonist. In nondiabetic male and female rats, acetylcholine and nitroglycerin produced dose-related dilatation of the basilar artery. However, the magnitude of vasodilatation in response to acetylcholine and a high concentration of nitroglycerin was significantly greater in female than in male rats. Acetylcholine (1.0 μM) dilated the basilar artery by 11±2% in nondiabetic males versus 25±4% in nondiabetic females (P<0.05). Nitroglycerin (1.0 μM) dilated the basilar artery by 37±8% in nondiabetic males versus 62±5% in nondiabetic females (P<0.05). Thus, there is a significant effect of gender on reactivity of the basilar artery during physiologic conditions. Dilatation of the basilar artery in response to acetylcholine, but not nitroglycerin, was impaired in diabetic male and female rats compared to their nondiabetic counterparts. Acetylcholine (1.0 μM) dilated the basilar artery by only 5±1% in diabetic males and by only 4±1% in diabetic females. In summary, dilatation of the basilar artery in response to NOS-dependent agonist was significantly greater in nondiabetic female than in nondiabetic male rats. In addition, diabetes mellitus impaired NOS-dependent dilatation of the basilar artery not only in male rats, but also in female rats. We suggest that the results of these studies provide insight into the pathogenesis of cerebrovascular abnormalities observed in postmenopausal women.

Original languageEnglish (US)
Pages (from-to)182-190
Number of pages9
JournalBrain Research
Volume930
Issue number1-2
DOIs
StatePublished - Mar 15 2002

Keywords

  • Acetylcholine
  • Brain
  • Cerebral circulation
  • Gender
  • L-NMMA
  • Nitric oxide
  • Nitroglycerin
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Influence of gender on dilatation of the basilar artery during diabetes mellitus'. Together they form a unique fingerprint.

Cite this